Neuro-Fuzzy Controller Design for Left Ventricular Assist Device Speed Regulation

Authors

  • Ruaa Radwan Computer Engineering Department, College of Engineering, Mustansiriyah University, Baghdad, Iraq
  • Ekhlas H. Karam Computer Engineering Department, College of Engineering, Mustansiriyah University, Baghdad, Iraq

DOI:

https://doi.org/10.31185/wjes.Vol14.Iss3.998

Keywords:

LVAD, cardiovascular system, control parameter, neural network, fuzzy

Abstract

The mechanical Left Ventricular Assist Device (LVAD) has become an important therapeutic device for patients with advanced heart failure. However, regulating LVAD pump speed under varying physiological conditions remains challenging due to the nonlinear and time-varying nature of the cardiovascular system (CVS). In this study, the CVS is represented using a lumped-parameter state-space model of the left ventricle derived from a nonlinear equivalent circuit. A model-free Neural Network PID (NN-PID) controller integrated with a fuzzy inference system is proposed for LVAD speed regulation. The NN-PID controller enables model-free pump speed control, while the fuzzy inference system adaptively tunes the controller parameters to accommodate changes in physiological conditions. Simulation results demonstrate that the proposed NN-PID controller improves pump-flow tracking accuracy and maintains the pump flow within an approximately physiological range of 1–4 L/min under varying operating conditions. The proposed controller also exhibits improved adaptability compared with the open-loop LVAD system.

Author Biography

  • Ekhlas H. Karam, Computer Engineering Department, College of Engineering, Mustansiriyah University, Baghdad, Iraq

    Department of Computer Engineering, Mustansiriyah University, Baghdad, Iraq.

References

[1] V. L. Roger, "Epidemiology of Heart Failure: A Contemporary Perspective," Circulation Research, vol. 128, no. 10, pp. 1421-1434, 2021, doi: 10.1161/CIRCRESAHA.121.318172. DOI: https://doi.org/10.1161/CIRCRESAHA.121.318172

[2] V. S. Vasudevan, K. Rajagopal, and J. F. Antaki, "Application of mathematical modeling to quantify ventricular contribution following durable left ventricular assist device support," Applications in Engineering Science, vol. 11, pp. 100107, 2022, doi: 10.1016/j.apples.2022.100107.

[3] M. Melendo-Viu, D. Dobarro, S. Raposeiras Roubin, C. Llamas Pernas, C. Moliz Cordón, M. Vazquez Lamas, M. Piñón Esteban, M. Á. Varela Martínez, E. Abu Assi, R. Pita Romero, J. J. Legarra Calderón, and A. Íñiguez Romo, "Left Ventricular Assist Device as a Destination Therapy: Current Situation and the Importance of Patient Selection," Life, vol. 13, no. 4, p. 1065, 2023, doi: 10.3390/life13041065. DOI: https://doi.org/10.3390/life13041065

[4] T. D. Cordeiro, D. L. Sousa, I. A. Cestari, and A. M. N. Lima, "A physiological control system for ECG-synchronized pulsatile pediatric ventricular assist devices," Biomedical Signal Processing and Control, vol. 57, p. 101752, 2020, doi: 10.1016/j.bspc.2019.101752. DOI: https://doi.org/10.1016/j.bspc.2019.101752

[5] L. G. E. Cox, S. Loerakker, M. C. M. Rutten, B. A. J. M. De Mol, and F. N. Van De Vosse, "A mathematical model to evaluate control strategies for mechanical circulatory support," Artificial Organs, vol. 33, no. 8, pp. 593-603, 2009, doi: 10.1111/j.1525-1594.2009.00755.x. DOI: https://doi.org/10.1111/j.1525-1594.2009.00755.x

[6] M. Yuzefpolskaya et al., "The Society of Thoracic Surgeons Intermacs 2022 Annual Report: Focus on the 2018 Heart Transplant Allocation System," The Annals of Thoracic Surgery, vol. 115, no. 2, pp. 311-327, 2023, doi: 10.1016/j.athoracsur.2022.11.023. DOI: https://doi.org/10.1016/j.athoracsur.2022.11.023

[7] M. Fetanat, M. Stevens, C. Hayward, and N. H. Lovell, "A Sensorless Control System for an Implantable Heart Pump Using a Real-Time Deep Convolutional Neural Network," IEEE Transactions on Biomedical Engineering, vol. 68, no. 10, pp. 3029-3038, 2021, doi: 10.1109/TBME.2021.3061405. DOI: https://doi.org/10.1109/TBME.2021.3061405

[8] J. Son, D. Du, and Y. Du, "Feedback Control of Rotary Blood Pump for Preventing Left Ventricular Suction," in Proc. 2019 American Control Conference (ACC), Philadelphia, PA, USA, 2019, pp. 5426-5430. DOI: https://doi.org/10.23919/ACC.2019.8814818

[9] V. C. A. Koh et al., "A centralized multi-objective model predictive control for a biventricular assist device: An in silico evaluation," Biomedical Signal Processing and Control, vol. 49, pp. 137-148, 2019, doi: 10.1016/j.bspc.2018.10.021. DOI: https://doi.org/10.1016/j.bspc.2018.10.021

[10] J. Son and Y. Du, "Model-Free Adaptive Control of the Failing Heart Managed by Mechanical Supporting Devices," in IFAC-PapersOnLine, 2022, pp. 750-755, doi: 10.1016/j.ifacol.2022.07.534. DOI: https://doi.org/10.1016/j.ifacol.2022.07.534

[11] M. Iscan and A. Yesildirek, "Modeling Transient Cardiovascular Hemodynamics with Physiological Conscious Autoencoder," IEEE Access, vol. 11, pp. 111909-111926, 2023, doi: 10.1109/ACCESS.2023.3322943. DOI: https://doi.org/10.1109/ACCESS.2023.3322943

[12] J. E. Traver et al., "Cardiovascular Circulatory System and Left Carotid Model: A Fractional Approach to Disease Modeling," Fractal and Fractional, vol. 6, no. 2, p. 64, 2022, doi: 10.3390/fractalfract6020064. DOI: https://doi.org/10.3390/fractalfract6020064

[13] M. Khaledi, M. Dehghani, R. Abolpour, and M. Mohammadi, "Controller Design for Left Ventricular Assist Devices in Patients with Heart Failure," in Proc. 2020 27th National and 5th International Iranian Conference on Biomedical Engineering (ICBME), Tehran, Iran, 2020, pp. 326-332, doi: 10.1109/ICBME51989.2020.9319420. DOI: https://doi.org/10.1109/ICBME51989.2020.9319420

[14] Y. S. Kim, E.-H. Kim, H.-G. Kim, E. B. Shim, K.-S. Song, and K. M. Lim, "Mathematical analysis of the effects of valvular regurgitation on the pumping efficacy of continuous and pulsatile left ventricular assist devices," Integrative Medicine Research, vol. 5, no. 1, pp. 22-29, 2016, doi: 10.1016/j.imr.2016.01.001. DOI: https://doi.org/10.1016/j.imr.2016.01.001

[15] G. Faragallah, Y. Wang, E. Divo, and M. A. Simaan, "A New Current-Based Control Model of the Combined Cardiovascular and Rotary Left Ventricular Assist Device," in Proc. 2011 American Control Conference (ACC), San Francisco, CA, USA, 2011, pp. 4775-4780, doi: 10.1109/ACC.2011.5990641. DOI: https://doi.org/10.1109/ACC.2011.5990641

[16] V. S. Vasudevan, K. Rajagopal, and J. F. Antaki, "Application of mathematical modeling to quantify ventricular contribution following durable left ventricular assist device support," Applications in Engineering Science, vol. 11, p. 100107, 2022, doi: 10.1016/j.apples.2022.100107. DOI: https://doi.org/10.1016/j.apples.2022.100107

[17] K. Gu, Y. Chang, B. Gao, Y. Liu, Z. Zhang, and F. Wan, "Lumped parameter model for heart failure with novel regulating mechanisms of peripheral resistance and vascular compliance," ASAIO Journal, vol. 58, no. 3, pp. 223-231, 2012, doi: 10.1097/MAT.0b013e31824ab695. DOI: https://doi.org/10.1097/MAT.0b013e31824ab695

[18] N. Westerhof, J. W. Lankhaar, and B. E. Westerhof, "The arterial Windkessel," Medical Engineering & Physics, vol. 31, no. 2, pp. 131-141, 2009, doi: 10.1007/s11517-008-0359-2. DOI: https://doi.org/10.1007/s11517-008-0359-2

[19] J. Son, D. Du, and Y. Du, "Modelling and control of a failing heart managed by a left ventricular assist device," Biocybernetics and Biomedical Engineering, vol. 40, no. 1, pp. 559-573, 2020, doi: 10.1016/j.bbe.2020.01.014.

[20] X. Liu et al., "Development of a Lumped Parameter Model of Human Whole Body Circulatory Loop," IEEE Access, vol. 12, pp. 188505-188518, 2024, doi: 10.1109/ACCESS.2024.3491112. DOI: https://doi.org/10.1109/ACCESS.2024.3491112

[21] Y. Bao, T. Jing, W. Ru, and L. Zhou, "Pulsatile Physiological Control of Blood Pump-Cardiovascular System Based on Feedforward Compensation," Micromachines, vol. 16, no. 6, p. 664, 2025, doi: 10.3390/mi16060664. DOI: https://doi.org/10.3390/mi16060664

[22] S. Wolpe, "A Heart Valve is a One-Way Valve that Allows Blood to Flow in One Direction through the Chambers of the Heart," Interventional Cardiology Journal, vol. 9, no. 2, p. 20, 2023, doi: 10.21767/2471-8157.9.02.20.

[23] L. F. V. Silva and T. D. Cordeiro, "A variable gain physiological controller for a rotary left ventricular assist device," in Proc. 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Virtual Conference, 2021, pp. 5606-5609, doi: 10.1109/EMBC46164.2021.9630835. DOI: https://doi.org/10.1109/EMBC46164.2021.9630338

[24] J. Son, D. Du, and Y. Du, "Modelling and control of a failing heart managed by a left ventricular assist device," Biocybernetics and Biomedical Engineering, vol. 40, no. 1, pp. 559-573, 2020, doi: 10.1016/j.bbe.2020.01.014. DOI: https://doi.org/10.1016/j.bbe.2020.01.014

[25] W. T. J. Al-Rubaye, A. S. Al-Araji, and H. A. Dhahad, "An Adaptive Digital Neural Network-Like-PID Control Law Design for Fuel Cell System Based on FPGA Technique," Journal of Engineering, vol. 26, no. 9, pp. 24-44, 2020, doi: 10.31026/j.eng.2020.09.03. DOI: https://doi.org/10.31026/j.eng.2020.09.03

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Published

2026-09-01

Issue

Section

Computer Engineering

How to Cite

Radwan, R., & Karam, E. (2026). Neuro-Fuzzy Controller Design for Left Ventricular Assist Device Speed Regulation. Wasit Journal of Engineering Sciences, 14(3), 106-119. https://doi.org/10.31185/wjes.Vol14.Iss3.998